In contrast with the majority of iron-sulfur proteins that function as electron carriers, the iron-sulfur cluster of aconitase reacts directly with an enzyme substrate. Aconitase has an active [Fe4S4] cluster, which may convert to an inactive [Fe3S4] form. Three cysteine (Cys) residues have been shown to be … See more Aconitase (aconitate hydratase; EC 4.2.1.3) is an enzyme that catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle, a non-redox-active process. • See more Aconitase, displayed in the structures in the right margin of this page, has two slightly different structures, depending on whether it is activated or inactivated. In the inactive form, its … See more • Aconitase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Proteopedia Aconitase - the Aconitase structure … See more Click on genes, proteins and metabolites below to link to respective articles. See more • Frishman D, Hentze MW (Jul 1996). "Conservation of aconitase residues revealed by multiple sequence analysis. Implications for structure/function relationships". … See more WebAconitases are iron-sulfur proteins which catalyze the reversible isomerization of citrate and isocitrate via cis -aconitate. While in mitochondria aconitase is part of the citric acid cycle, in the cytosol aconitase is a trans-regulatory factor that controls iron homeostasis at a post-transcriptional level.
E. coli aconitase B structure reveals a HEAT-like domain with ...
Web23 Aug 2024 · 4.2: Levels of Protein Structure. 4.4: Protein folding. Henry Jakubowski. College of St. Benedict/St. John's University. Secondary structures are those repetitive structures involving H bond between amide H and carbonyl O in- the main chain. These include alpha helices, beta strands (sheets) and reverse turns. WebAconitases are iron-sulfur proteins which catalyze the reversible isomerization of citrate and isocitrate via cis -aconitate. While in mitochondria aconitase is part of the citric acid cycle, … neeraj chopra javelin throw final
Missense Mutation - Genome.gov
Web1 Jan 2006 · In this issue of Structure, Volbeda, Fontecilla-Camps, and colleagues (Dupuy et al., 2006) present the first structure of a eukaryotic cytoplasmic aconitase (cAcn). Their work casts new light on the crucial RNA binding function of some of the members of the aconitase superfamily. ... Human cytoplasmic aconitase (cAcn) has the same overall ... WebDescription. A severe autosomal recessive neurodegenerative disorder characterized by onset between ages 2 and 6 months of truncal hypotonia, athetosis, seizures, and … WebThe enzyme aconitase is a key player in the central pathway of energy production. As part of the citric acid cycle , it converts citrate into isocitrate. There is one form of aconitase in our mitochondria, which performs most … ith and kin