Gdh1 cancer

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August undefined, 2024

WebJul 16, 2024 · GDH1 was downregulated in KIRC tissues, particularly at the protein level, indicating that the decreased expression of GDH1 would facilitate renal cancer initiation … WebJan 4, 2024 · Compound R162, as a first generation of GDH1 small-molecule inhibitor for GDH1-targeted lung cancer therapy, has shown promising efficacy in the treatment of …

α-Ketoglutarate-Activated NF-κB Signaling Promotes …

WebIntroduction. Hepatocellular carcinoma (HCC) is the fifth most common cancer and the fourth leading cause of cancer mortality globally. 1 The patients with HCC have a poor … WebFeb 9, 2015 · GDH1 is important for redox homeostasis in cancer cells by controlling the intracellular levels of its product alpha-ketoglutarate and subsequent metabolite … indy oral and maxillofacial

Toward the next generation EGFR inhibitors: an overview of …

WebJul 16, 2024 · Tumor cells need to cope with nutritional exhaustion during cancer progression. A mechanism downregulating glutamate dehydrogenase 1 (GDH1) and … WebOct 3, 2024 · These findings highlight a novel role of GDH1 in reprogramming cancer metabolisms that is distinguished from its classical role in the mitochondria. Notably, overexpression of the phosphor-deficient mutant form of GDH1 (GDH1 S384A) drastically attenuated glioma growth in a GLUT1-dependent manner in the in vivo murine models. WebIntroduction. Gastric cancer (GC) is an aggressive malignancy and a common cause of cancer-related deaths worldwide. An estimated 27,510 new cases will be diagnosed in the USA in 2024 with a mortality of 11,140 cases. 1 The overall 5-year survival rate for all types and stages of gastric cancer in the United States was 31% (2008–2016) with a range of … indy open wheel schedule

Physiological Role of Glutamate Dehydrogenase in Cancer Cells

Glutamate dehydrogenase 1 mediated glutaminolysis ... - Journal of Cancer

WebDiffuse gastric cancer is a specific type of stomach cancer, sometimes also called “signet ring cell gastric cancer” or “linitis plastic.”. The word "diffuse" is used because this … WebFilter Results: Year. 2015 (4); 2024 (4); 2024 (4); 2014 (2); 2016 (2); 2024 (2); 2024 (2); 2008 (1); 2009 (1); 2010 (1); 2013 (1); 2024 (1); 2024 (1); Author. Zhou ... login iowa unemployment weekly claimsWebFeb 9, 2015 · Highlights • GDH1 predominantly controls intracellular α-KG and subsequent fumarate levels • GDH1 contributes to redox … log in iosh

"WebHereditary diffuse gastric cancer is caused by germline mutations in the epithelial cadherin (CDH1) gene and is characterized by an increased risk for diffuse gastric cancer and lobular breast cancer. To determine whether recurring germline CDH1 mutations occurred due to independent mutational events or common ancestry. " - Gdh1 cancer

Gdh1 cancer

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and

WebAlthough enhanced glutaminolysis is one of the hallmarks of cancer metabolism, little is known about its role in tumor metastasis. We recently reported that GDH1 expression correlates with metastatic potential in NSCLC patients. WebFeb 4, 2024 · The glutaminolytic enzyme glutamate dehydrogenase 1 (GDH1) was shown to confer anoikis resistance, which is required for metastasis, in LKB1-deficient lung cancer cell lines. The transcription …

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WebJan 22, 2024 · The metabolism of glutamate into α-ketoglutarate is catalyzed by glutamate dehydrogenase 1 (GDH1), glutamate pyruvate transaminase 2 (GPT2), or glutamate oxaloacetate transaminase 1 and 2 (GOT1 (cytoplasmic) and GOT2 (mitochondrial)), which were al previously reported to be overexpressed in cancer [ 89, 90, 91, 92 ]. WebOct 7, 2024 · NADPH-dependent biological functions in cancer. There are three principal ways in which NADPH is used. First, NADPH is an essential cofactor of glutathione reductase (GR) and TRXR in GSH and TRX ...

http://www.ott.emory.edu/industry/featured/gdh1.html#:~:text=GDH1%20plays%20a%20key%20role%20in%20cancer%20growth,with%20minimum%20toxicity%20to%20normal%20cells%2C%22%20Kang%20says. WebApr 22, 2024 · Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration stimulates tumorigenesis and supports the progression of cancer cells, while an excessive concentration leads to cell death. The upregulated antioxidant system in …

WebSep 17, 2024 · Cancer cells in tumors with IDH1 or IDH2 mutations show oncogenic activity by converting glutamine-derived α-KG to 2-hydroxyglutarate (2-HG), which competitively inhibits α-KG-dependent histone... WebFeb 2, 2024 · There is no clear association between αKG and colorectal cancer (CRC), especially as the underlying molecular mechanisms of αKG-mediated CRC progression are still elusive. We observed that GDH1 deficiency had an inhibitory effect on the occurrence of CRC and impelled hypoxia-inducible factor 1-alpha (HIF1α) instability even under hypoxia.

WebJul 7, 2016 · Silencing GDH1 in human cancer cells led to elevated ROS level and decreased cell proliferation both in vitro and in vivo, indicating that cellular redox …

WebDec 13, 2024 · In line with this observation, Y135F mutation decreased GDH1 activity in cancer cells, whereas the effect was abolished in the presence of EGFR inhibitor erlotinib (Figure 5I). To explore the functional … login ioxWebCollectively, all the data showed that GOT1 catalyzed glutamine transamino-metabolism played a major role on HCC cells survival when glucose is high, while GDH1 mediated deamino-metabolism played a leading role on cells survival when glucose is insufficient, implying that major glutaminolysis pathways of HCC cells could change under different … log in iowa stateWebFeb 7, 2024 · GDH1 is a glutamate dehydrogenase that plays a predominant role in converting glutamate to α-KG in cancer cells . … indy oral surgeryWebJul 2, 2024 · Introduction. Gastric cancer (GC) is the third leading cause of cancer death worldwide [].GC is a histologically heterogeneous cancer. Most GCs are adenocarcinomas and are classified into 2 main histological types: intestinal type and diffuse type, according to the Lauren classification [].These subtypes show biological differences in regional … log in iphone from broke phoneWebR162-DataSheet-生命科学试剂-MedChemExpress.pdf,I n Product Data Sheet h i b i t o r s R162 • A g o n Cat. No.: HY-103096 i s t CAS No.: 64302-87-0 s Molecular Formula: C₁₇H₁₂O₃ • S c Molecular Weight: 264.28 r e e Target: Others n i n g L Pathway: Others i b r Storage: Powder -20°C 3 years a r i login iperms hrcWebOct 3, 2024 · GDH1 is ubiquitously expressed and commonly upregulated in many human cancers, such as glioma, breast cancer, lung cancer, and leukemia (Michaelidis et al., 1993, Zaganas et al., 2012). GDH1 plays an important role in tumor progression. login iphone notesWebCox model analysis revealed that CDH1 methylation status in preoperative peritoneal lavage fluid was an independent factor associated with postoperative survival in patients with gastric cancer(P=0.000, RR=332.88, 95%CI:21.71-5105.07). Conclusions: The aberrant methylation of 5'-CpG of CDH1 gene promoter is common in gastric cancer. The ... login ipledge